A prime opportunity is in front of Christian McCaffrey when the San Francisco 49ers play the Los Angeles Rams in Week 10. McCaffrey can become the first player

They’ll face a Rams team that stands atop the NFC West at 6-2, coming off three straight wins over the Baltimore Ravens, Jacksonville Jaguars, and the New Orleans Saints. All three of those victories have come by at least 14 points, with Los Angeles eclipsing the 30-point mark in the last two.

Unleash your fantasy stars like McCaffrey and Williams. Avoid defenses; watch for unexpected breakouts in this NFC West clash.

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The Los Angeles Rams and San Francisco 49ers will meet on Sunday, and Sean McVay's team is calling up two players from the practice squad.

San Francisco tight end George Kittle explained why the 49ers' games against the Los Angeles Rams stand out to him ahead of their Week 10 matchup.

Kyle Shanahan and Sean McVay have faced off 18 times leading their respective teams, with Shanahan currently holding an 11–7 edge over McVay. But those head-to-head matchups only tell part of the story of the rivalry between these two sides. While both men first got their shot at a top NFL job in 2017, their history goes back further.