Though there is so much to learn about the way Alzheimer's develops in the human brain, amyloid beta proteins have long been implicated in its advance. A new study has uncovered a previously unknown ...

In this collection, we highlight papers reporting structural insights into amyloid fibrils associated with neurodegenerative and systemic diseases as well as functional amyloids that were obtained ...

(a) Single-molecule localization microscopy of a network of amyloid aggregates. (b) Nile red binding orientations to amyloid surfaces. (c-g) Individual orientation measurements along fibril backbones ...

Neurodegenerative diseases such as Parkinson’s and Alzheimer’s are accompanied by amyloid proteins that have been misfolded. However, the mechanism by which protein misfolding and aggregation trigger ...

Solving the structure of an amyloid protein gives new insight into limb-girdle muscular dystrophy type 3 (LGMD D3) and functional protein aggregation. LGMD D3 is a rare disease characterized by slow ...

Brain cells are constantly swallowing material from the fluid that surrounds them—signaling molecules, nutrients, even pieces of their own surfaces—in a process known as endocytosis that is essential ...

Amyloid-beta (Aβ) accumulation in the brain is proposed to be an early toxic event in the pathogenesis of Alzheimer’s disease (AD). Although there have been many studies done, there is great ...

This is a preview. Log in through your library . Abstract Amyloid-β (Aβ) fibrils exhibit self-propagating, molecular-level polymorphisms that may contribute to variations in clinical and pathological ...

By far the strongest genetic risk factor for Alzheimer’s disease is a variant of apolipoprotein E, or ApoE. People who carry ...

Amyloid-beta (A-beta) aggregates are tangles of proteins most notably associated with neurodegenerative diseases like Alzheimer's. Despite its constant stint in the limelight, however, researchers ...

Researchers have developed a microscopy technique to visualize amyloid beta’s underlying structure, which could yield new insights into Alzheimer’s disease. As the prevalence of Alzheimer’s rises, ...