Researchers from Tokyo Medical and Dental University (TMDU) and Ionis Pharmaceuticals, USA, report a modification wherein replacing the RNA strand of a heteroduplex oligonucleotide with DNA may ...

In recent years, scientists have found that RNA--once thought to be little more than a bit player in the pathway from gene to protein--stands more center stage, playing a larger and more varied ...

Dartmouth Medical School geneticists studying the biological clock have opened yet another window into the role of an unusual form of RNA known as antisense that blocks the messages of ...

For sure? No. <br><br>But the mRNA follows the "sense" of the sense strand, which seems like a logical and sufficient naming convention. Even if it's really the antisense strand that's used as the ...

In recent years, two antisense oligonucleotide therapies have hit the market, at least nine more are in clinical trials for the treatment of neurologic diseases, and nearly two dozen are in ...

TRANSLATING DNA into proteins may be an even more complex business than anyone thought. In the conventional picture, only one of the twin strands that make up the DNA double helix – the so-called ...

Researchers have devised a molecular structural modification that boosts the efficacy of antisense oligonucleotide-based drugs by replacing the RNA strand of a heteroduplex oligonucleotide with DNA.