Warsaw breakage syndrome (WABS) is caused by defective DDX11, a DNA helicase that is essential for chromatid cohesion. Here, a paired genome-wide siRNA screen in patient-derived cell lines reveals ...

The formation of mitotic chromosomes requires both compaction of chromatin and the resolution of replicated sister chromatids. Compaction occurs during mitotic prophase and prometaphase, and in ...

Since sister chromatids are identical to each other, recombination with a sister chromatid is expected, in most cases, to be a precise way for repairing DNA damage. Recombination between 2 different ...

Researchers from Tokyo Metropolitan University have developed a suite of algorithms to automate the counting of sister chromatid exchanges (SCE) in chromosomes under the microscope. Conventional ...