Christina A. Sheil, MD, explains why polypharmacy has become one of the most significant challenges in modern healthcare.

While reductionism has advanced biology and medicine, it fosters a fragmented understanding of health, ill-suited to modern challenges like chronic and systemic diseases. Systems biology offers a new ...

Systems biology aims to achieve holistic insights into the molecular workings of cellular systems through iterative loops of measurement, analysis and perturbation. This framework has had remarkable ...

Modeling complex systems When studying complex biological systems such as the immune system, scientists can extract many different types of data. Sequencing cell genomes tells them which gene variants ...

Systems biology is a rapidly evolving discipline that examines the complex interactions underlying biological function ...

The beautiful, fascinating and often perplexing world around us grows from intricate and convoluted interactions of millions of pieces. As scientists, we work to understand and describe the parts and ...

Ever better experimental techniques allow us to perform experiments under tightly controlled conditions and can deliver gigantic amounts of data reflecting the complexity of biology. This has vastly ...