Gene syntax alters DNA supercoiling to amplify or suppress nearby genes. This could improve the effectiveness of gene ...

Gene expression—the way our DNA turns into working molecules—shapes everything from how cells grow to how diseases develop.

RNA polymerase, the enzyme that synthesizes RNA from DNA during transcription, has been captured mid-reaction for the first ...

Gene expression is controlled, in part, by the interactions between genes and regulatory elements located along the genome.

When a gene is turned on in a cell, it creates a ripple effect along the DNA strand, changing the physical structure of the ...

Much of the phenotypic variation that is observed within and between species is the result of differences in gene regulation: specifically when, where and how much the genes are expressed. Given the ...

Researchers at the Jackson Laboratory (JAX), the Broad Institute of MIT and Harvard, and Yale University, have used artificial intelligence (AI) to design thousands of new DNA switches that can ...

Epigenome editing has followed a similar path, in that more recent technological breakthroughs have enabled scientists to apply the discoveries made in previous decades. Epigenome editing performs a ...

Water molecules play an active, essential role in gene transcription, helping RNA polymerase II carry out the chemical steps ...

DNA methylation is a key epigenome component that helps dictate how genes are expressed, contributing to normal cell and tissue differentiation during development, as well as the process of biological ...

A new international study suggests that ancient viral DNA embedded in our genome, which were long dismissed as genetic "junk", may actually play powerful roles in regulating gene expression. Focusing ...