From vaccines and diagnostics to emerging gene-based therapies, RNA molecules are now central to modern medicine. But as ...

Researchers developed C28, an engineered polymerase that efficiently synthesizes RNA at near-natural speeds with high accuracy. Created through directed evolution, the enzyme also performs reverse ...

While most enzymatic activity is conducted through chemical binding interactions between molecules, in some cases, the mere presence of an enzyme can affect intracellular functions. While exploring ...

Amide bonds are common in drugs because they are chemically stable, form readily and are biocompatible. They also help ...

After a long search, RIKEN researchers have identified an enzyme crucial for keeping lipid-linked sugar chains in check in ...

The authors’ approach is deceptively simple: take an aldehyde dehydrogenase enzyme, which naturally converts aldehydes to acids, and get it to react with an amine instead of water. But actually making ...

A single type of chemical structure that shows up again and again in modern medicine is the amide bond that links a carbonyl ...

Genetic medicines R&D is making strides with more complex DNA molecules. While these long sequences of synthetic DNA are key for developing gene and cell therapies as well as antibodies and other ...

NUDT5 enzyme acts as a molecular scaffold that maintains metabolic balance. Inside every cell, a finely tuned metabolic network determines when to build, recycle or stop producing essential molecules.

Man prides himself upon his growing mastery over nature, but in the ultimate biochemical analysis nature remains the master of man. With their most sophisticated laboratory glassware and corrosive ...