HIV fusion and entry are two steps in the viral lifecycle that can be targeted by several classes of antiviral drugs. The discovery of chemokines focused the attention on cellular co-receptors used by ...

In the absence of antiviral therapy, infection by HIV-1 typically leads to AIDS and death 1,2. Entry of HIV-1 into target cells is mediated by the interaction of the viral Envs with the CD4 receptor ...

A new study overthrows a long-held theory on how HIV finds its way into host cells. Rather than fusing directly with the host cell membrane, the virus is first engulfed by it to form a vesicle that ...

“There have been as many plagues as wars in history; yet always plagues and wars take people equally by surprise.” ― Albert Camus, The Plague As the world strives to find a cure for the ongoing ...

Circumcision seems to arm men with a degree of protection against HIV, the AIDS virus, but the mechanism underlying this defense has been unclear. A new study bolsters earlier reports implicating the ...

As enemies go, the human immunodeficiency virus has proven particularly shrewd at evading attempts to defeat it. Decades into the fight against HIV, statistics on the virus’s toll are still staggering ...

The chemokine receptors CCR5 and CXCR4 are the two major coreceptors for HIV entry. Numerous efforts have been made to develop a new class of anti-HIV agents that target these coreceptors as an ...

HIV-1 virions are highly enriched in cholesterol relative to the cellular plasma membrane. We recently reported that a cholesterol-binding compound, amphotericin B methyl ester (AME), blocks HIV-1 ...