The X-Men have some powerful mutants, and these are the ones who would have the best chance in a fight with the Hulk.
It took Marvel more than a few tries to finally get the Incredible Hulk right, and that involved canceling the character's comic original comic series.
The Hulk is one of Marvel’s most interesting characters for numerous reasons, but the one that sticks out the most is that he’s not actually a superhero. This was honestly there from the beginning.