The US Food and Drug Administration (FDA) is exploring the use of model master files (MMFs) to enable sponsors to use the same modeling approach to support different generic drug development programs, ...

Does using alcohol, nicotine, or cannabis engender addiction by changing the structure of brains, or does the structure of brains incline some people toward using those substances? In standard brain ...

Scientists at The Scripps Research Institute (TSRI) have found that deep brain stimulation (DBS) can greatly reduce the compulsion to use heroin in standard rat models of addiction. Rats that were ...

For decades, the pharmaceutical industry has discussed moving away from in vivo models in preclinical research. Now, it’s more than a conversation. The FDA’s roadmap for reducing animal testing, ...

Inductive Bio, an AI drug discovery partner developing virtual chemistry labs, received an up to $21M award to lead a project to develop next-generation models of drug toxicity to advance safer ...

Researchers at Kanazawa University identified dopamine-driven neural mechanisms of motivation in a mouse model of behavioral addiction, offering insights into treatment. Assistant Professor Naoya ...

Despite decades of progress in pharmaceutical R&D, the earliest phase of drug discovery—where molecules are conceived and designed—remains costly, inefficient, and burdened by high failure rates. Most ...

Grace Point Treatment Center has released an educational article examining “how drug addiction is assessed and treated within licensed clinical environments”. The resource is positioned as an ...

Remarkable scientific progress over the past five decades has helped us develop knowledge of how drugs of abuse induce pleasure, reinforce use, and lead to the compulsive self-administration we call ...