The nucleolus—a conspicuous but obscure organelle within the cell nucleus—is normally too compact to be studied in detail. Researchers at Case Western Reserve University just learned how to simplify ...

Research at the University of Jyväskylä (Finland) reveals that autonomous parvoviruses, such as canine parvovirus, are highly capable of affecting the internal balance of the nucleolus. The results ...

At most, 10 people in the world are known to have BPTA. Five of them participated in the current study, and they were found to share virtually the same mutation in the gene for the HMGB1 protein. It ...

Biologists discovered that a scaffolding protein called TCOF1 is responsible for the formation of a biomolecular condensate called the fibrillar center, which forms within the cell nucleolus. Inside ...

The size of a cell's nucleolus may reveal how long that cell, or even the organism it belongs to, will live. Over the past few years, researchers have been piecing together an unexpected link between ...

The secret to cellular youth may depend on keeping the nucleolus—a condensed structure inside the nucleus of a cell—small, according to Weill Cornell Medicine investigators. The findings were ...

Knowing when you’re going to die is a fact best left unexplored. But for better or for worse, scientists have discovered a part of human cells that is tightly linked to the aging process, and it may ...

The ubiquitin-like molecule NEDD8 is essential for viability, growth and development, and is a potential target for therapeutic intervention. We found that the small molecule inhibitor of NEDDylation, ...

In a recent study published in the Proceedings of the National Academy of Sciences (PNAS), researchers at the Texas A&M University Health Science Center (Texas A&M Health) identify a novel RNA ...