The authors set out to answer a simple question. Do all chromosomes have the same chance of being mis-segregated during cell division? To address this, Klaasen and colleagues turned to several types ...
Researchers have made a significant advancement toward understanding how the human genome is organized inside a single cell. This knowledge is crucial for analyzing how DNA structure influences gene ...
Despite being densely packed to fit into the nucleus, chromosomes storing our genetic information are always in motion. This allows specific regions to come into contact and thereby activate a gene. A ...
Despite being densely packed to fit into the nucleus, chromosomes storing our genetic information are always in motion. This allows specific regions to come into contact and thereby activate a gene. A ...
Chromosomes are thread-like structures located inside the nucleus of animal and plant cells. Each chromosome is made of protein and a single molecule of deoxyribonucleic acid (DNA). Passed from ...
Nucleosomes (blue sphares) in active chromatin regions form condensed domains with local nucleosome contacts and cohesin (rings), where nucleosomes fluctuate. Each interphase chromosome (highlighted ...
The first theoretical model of condensin, a molecular machine involved in packing and unpacking chromosomes, accurately reproduces all known experiments with just two parameters. To scrunch a ...
M. Jagannathan et al., “A conserved function for pericentromeric satellite DNA,” eLife, 7:e34122, 2018. Between cell divisions, pericentromeric DNA—noncoding, repetitive satellite DNA abundant around ...
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