Proton pump inhibitor therapy is well tolerated at standard doses; even a fivefold increase in the AUC of PPIs appears to cause only negligible side effects. The clinical relevance of these ...
Most antidepressants are metabolized through the cytochrome P (CYP) 450 pathway; therefore, most drug metabolism genes on pharmacogenetic testing panels are related to CYP450 oxidase enzyme subunits.
Genetic polymorphisms have been described in the case of several CYP isoenzymes. The best explored example of this phenomenon is the CYP2C19 polymorphism. In this table the most frequent alleles are ...
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