IL-21 is a type I cytokine essential for immune cell differentiation and function. Although IL-21 can activate several STAT family transcription factors, previous studies focused mainly on the role of ...
New data shows Telomir-1 fully reverses STAT1 gene silencing by DNA methylation – a key immune regulator suppressed in cancer – delivering stronger epigenetic effects than Paclitaxel or Rapamycin in ...
Researchers from Tokyo Medical and Dental University (TMDU) find three novel variants in STAT1 that cause Mendelian susceptibility to mycobacterial disease Tokyo, Japan – Usually, the scariest part of ...
The first ever study assessing how patients with "gain of function" mutation of the STAT1 gene respond to stem cell transplantation has taken place, yielding disappointing results, say researchers.
When a virus infects an individual, a complex human immune response is initiated to limit the effects of the viral invasion. One of the several different immune responses that can arise following a ...
In summary, macrophages secrete IFN-β, activating the IFN-β-IFNAR-p-STAT1 axis in MICFs, leading to increased secretion of CCL2/7/12 chemokines and subsequent recruitment of more IFN-β-secreting ...
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