The discovery of Hoogsteen base pairs, an alternative pairing mode to the canonical Watson–Crick structure, has significantly broadened our understanding of DNA dynamics. This conformation, in which ...

Metal-mediated base pairing in nucleic acids represents a transformative approach wherein traditional Watson–Crick hydrogen bonds are replaced or supplemented by coordinate bonds with metal ions. This ...

This image illustrates the chemical structures of the five main nucleobases found in DNA and RNA. The pyrimidines, thymine (DNA), uracil (RNA), and cytosine are shown on top while the purines, adenine ...

DNA, the blueprint of life, is best known for its fundamental role as genetic material—storing and transmitting biological information through the precise sequence of its bases. For decades, this ...

Scientists have for the first time been able to build a organism containing a new, synthetic pair of DNA units, marking a breakthrough in the field of synthetic biology that has major implications for ...