Figure 1: β-catenin and cytoplasmic dynein localize together at adherens junctions. To determine whether the localization of dynein to adherens junctions is sensitive to the disruption of either ...

Dr. Jonas Wilson, MD, Ing. Med. Dynein, one of three cytoskeletal motor protein families, was first identified a half century ago and got its name after the ‘dyne’ (i.e. a unit of force). Motor ...

Intracellular protein aggregation is a common theme in neurodegenerative disease. The formation of aggregates is blamed on protein overproduction, a failure of clearance, or both. Score one for the ...

A mechanism of dynein-powered metastatic locomotion has been identified using soft tissue models, revealing a new clinical target for breast cancer treatment. New research led by Penn State (PA, USA) ...

In research published in the Journal of Cell Biology, scientists from the RIKEN Brain Science Institute in Japan have made important steps toward understanding how dynein—a "molecular motor"—walks ...

Our cells rely on microscopic highways and specialized protein vehicles to move everything—from positioning organelles to carting protein instructions to disposing of cellular garbage. These highways ...

The motor protein dynein, which carries molecular cargo along microtubule tracks in cells, is less understood than other motor proteins such as kinesin and myosin. Dynein's motor region consists of a ...

Dynein transports various cellular cargo by "walking" along cytoskeletal microtubules towards the minus-end of the microtubule, which is usually oriented towards the cell center. Thus, they are called ...

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