Cardiovascular and metabolic health are influenced by the circadian system, which regulates 24-hour rhythms across numerous physiologic processes. Disruptions to circadian rhythmicity can adversely ...

BACKGROUND: A 3-dimensional hyperboloid model has been proposed to characterize ventricular tachycardia (VT) circuitry. We ...

Background: Cardiovascular disease (CVD) causes more than 50% of deaths in patients with advanced chronic kidney disease (CKD). Clinical studies suggest that kidney-derived factors contribute to CVD ...

Background: Patients with prior ischemic stroke are at high risk for recurrent stroke and other major adverse cardiovascular events (MACE). The benefits of achieving very low levels of low-density ...

Background: Little correlation exists between the burden of ischemia and severity of angina in patients with stable coronary artery disease. This placebo-controlled, n-of-1 study investigated the ...

• The seventh sentence read, “Therefore, only the eligibility criteria from these trials should be used for patient selection.” It has been updated to read, “Therefore, only the eligibility criteria ...

eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are ...

We have recently shown that the extracellular matrix molecule agrin promotes heart regeneration after myocardial infarction in nonregenerating mouse hearts. 5 To determine whether agrin affects ...

Platypnea-orthodeoxia is a relatively uncommon but striking clinical syndrome characterized by dyspnea and deoxygenation accompanying a change to a sitting or standing from a recumbent position. Since ...

In the drug development world, the US Food and Drug Administration would require extensive safety testing before approval of a drug that caused this degree of QT prolongation in a “thorough QT/QTc ...

Cardiac magnetic resonance imaging can identify rare causes of recurrent stroke, such as congenital ventricular diverticulum. Congenital ventricular diverticulum is a protrusion of all 3 cardiac ...

The American Heart Association, in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors ...