A prime opportunity is in front of Christian McCaffrey when the San Francisco 49ers play the Los Angeles Rams in Week 10. McCaffrey can become the first player

They’ll face a Rams team that stands atop the NFC West at 6-2, coming off three straight wins over the Baltimore Ravens, Jacksonville Jaguars, and the New Orleans Saints. All three of those victories have come by at least 14 points, with Los Angeles eclipsing the 30-point mark in the last two.

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The Los Angeles Rams spoke in depth on what a difference the 49ers defense is like without Fred Warner on the field

Unleash your fantasy stars like McCaffrey and Williams. Avoid defenses; watch for unexpected breakouts in this NFC West clash.

The Los Angeles Rams and San Francisco 49ers will meet on Sunday, and Sean McVay's team is calling up two players from the practice squad.

Running it heavily against the Rams with McCaffrey and Robinson is pivotal for the 49ers. Doing so will enhance the offense and their chances for victory. Follow Jose on X (Twitter) @JS3sanchez_to interact with him on the 49ers.

San Francisco tight end George Kittle explained why the 49ers' games against the Los Angeles Rams stand out to him ahead of their Week 10 matchup.