Familiar matchups abound on the NFL Week 10 schedule as there are half a dozen divisional games you can make Week 10 NFL picks on. The highlight of that slate is Rams vs. 49ers, which has L.A. as the 4.

Charles Woodson and Julian Edelman discuss whether the San Francisco 49ers or Los Angeles Rams will not only win their Week 10 showdown but which team will ultimately win the NFC West.

An incident involving San Francisco 49ers star running back Christian McCaffrey led to a punishment from the NFL this weekend.

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The San Francisco 49ers are looking to string two wins together for the first time since starting 3-0 as they host the Los Angeles Rams in Week 10.  It’ll be a

Asante Samuel Jr. to boost secondary after injuries. Analyst explains urgency, fit, and postseason Super Bowl impact.

The latest edition of Newsweek Sports Betting 📩 includes Rams vs. 49ers best bets and NFL Week 10 picks against the spread.

An interesting Week 10 slate is set for Sunday, Nov. 9, and there are plenty of bets to consider across the board. Luckily, the SI Betting team has things narro

Then there’s this noteworthy trend: While the over has hit in each of the last four Bills-Dolphins meetings in Buffalo and 10 of the last 11 — with nine reaching or exceeding 50 points — the under has cashed in each of the last four battles in Miami. Final scores: 35-0, 21-19, 21-14 and 31-10.