Wickliffe, Kentucky — Small Town, Big History Nestled along the Mississippi River, Wickliffe, KY is a town rich in history and heritage. Established in the mid-1800s, Wickliffe has long served as a gateway between Kentucky and the Mississippi River trade routes. One of its most fascinating landmarks is the Wickliffe Mounds State Historic Site, an ancient Native American archaeological site built by the Mississippian culture between 1100–1350 AD. These mounds remind us that Wickliffe’s story bega