How a Gila monster's venom became a diabetes drug.
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YouTubePhenomica
How a Gila monster's venom became a diabetes drug.
Exendin-4, a 39-amino-acid peptide isolated from the venom of the Gila monster (Heloderma suspectum), is a glucagon-like peptide-1 (GLP-1) receptor agonist resistant to dipeptidyl peptidase-4 (DPP-4) degradation — the property that made it the basis of the first GLP-1-based diabetes therapy. GLP-1 is an incretin hormone released by intestinal ...
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